An AP-3-dependent mechanism drives synaptic-like microvesicle biogenesis in pancreatic islet -cells
نویسندگان
چکیده
Arthur T. Suckow, Branch Craige, Victor Faundez, William J. Cain, and Steven D. Chessler Department of Medicine and Pediatric Diabetes Research Center; Biomedical Sciences Graduate Program, University of California San Diego, La Jolla, California; Graduate Program in Biochemistry, Cell, and Developmental Biology and Department of Cell Biology and Center for Neurodegenerative Diseases, Emory University, Atlanta, Georgia; and Department of Biological Sciences, University of Delaware, Newark, Delaware
منابع مشابه
An AP-3-dependent mechanism drives synaptic-like microvesicle biogenesis in pancreatic islet beta-cells.
Pancreatic islet beta-cells contain synaptic-like microvesicles (SLMVs). The origin, trafficking, and role of these SLMVs are poorly understood. In neurons, synaptic vesicle (SV) biogenesis is mediated by two different cytosolic adaptor protein complexes, a ubiquitous AP-2 complex and the neuron-specific AP-3B complex. Mice lacking AP-3B subunits exhibit impaired GABAergic (inhibitory) neurotra...
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The lumenal ionic content of an organelle is determined by its complement of channels and transporters. These proteins reach their resident organelles by adaptor-dependent mechanisms. This concept is illustrated in AP-3 deficiencies, in which synaptic vesicle zinc is depleted because the synaptic-vesicle-specific zinc transporter 3 does not reach synaptic vesicles. However, whether zinc transpo...
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The formation of small vesicles is mediated by cytoplasmic coats the assembly of which is regulated by the activity of GTPases, kinases, and phosphatases. A heterotetrameric AP-3 adaptor complex has been implicated in the formation of synaptic vesicles from PC12 endosomes (). When the small GTPase ARF1 is prevented from hydrolyzing GTP, we can reconstitute AP-3 recruitment to synaptic vesicle m...
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تاریخ انتشار 2010